Postsplenectomy Thrombocytosis and Managements
نویسندگان
چکیده
منابع مشابه
Hemorrhagic thrombocythemia; control of postsplenectomy thrombocytosis with melphalan.
Hemorrhagic thrombocythemia is a relatively well-defined myeloproliferative disease in which the major abnormality is the excessive production of megakaryocytes and platelets. In its natural evolution acute and chronic bleeding from the gastrointestinal tract, thromboembolic phenomena, gastric and esophageal varices, and infarction atrophy of the spleen are the important clinical features. Disa...
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Immune thrombocytopenic purpura (ITP) causes thrombocytopenia through the autoimmune destruction of platelets. Corticosteroids remain the first line of therapy, and traditionally splenectomy has been the second. While the availability of thrombopoietin receptor agonists (TPO-RAs) has expanded treatment options, there is little data for the ideal management of these agents in preparation for spl...
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This report aims to deepen the understanding of the pathogenesis, diagnosis, clinical characteristics, and treatment of overwhelming postsplenectomy infection (OPSI). A patient treated at Taihe Hospital for tuberculous OPSI is described, and relevant literature is reviewed. Broad-spectrum antibiotics, suppression of the systemic inflammatory reaction, and anti-shock measures were the keys to th...
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The study of Hegarty et al. shows that two thirds of splenectomised patients are unaware of an increased risk of severe infectious diseases and cites nine recommendations to prevent severe infections. These data con®rm the ®ndings of several other studies. The Department of Haematology at Heinrich-HeineUniversity of DuÈ sseldorf has adopted an intense counselling attitude towards asplenic patie...
متن کاملThrombocytosis.
Major progress in understanding the pathogenesis in patients with thrombocytosis has been made by identifying mutations in the key regulators of thrombopoietin: the thrombopoietin receptor MPL and JAK2. Together, these mutations can be found in 50% to 60% of patients with essential thrombocythemia or primary myelofibrosis and in 10% to 20% of hereditary thrombocytosis. A decrease in expression ...
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ژورنال
عنوان ژورنال: Open Access Journal of Surgery
سال: 2018
ISSN: 2476-1346
DOI: 10.19080/oajs.2018.08.555728